Jeremy F. Reiter, MD, PhD
Professor and Chair, Department of Biochemistry and Biophysics, UCSF
Cancer Center Program Memberships
Pediatric MalignanciesResearch Summary
Jeremy Reiter is the chairperson of the Department of Biochemistry and Biophysics. His lab investigates how cilia form, signal and function in intercellular communication. Their achievements include:
1. The discovery that Smoothened, a critical component of the Hedgehog pathway, localizes to and works in cilia. This was the first demonstration that the Hedgehog signal transduction machinery functions at cilia.
2. They were the first to show that cancers can be ciliated and that cancers can require cilia for growth.
3. They helped show that the region at the base of the cilium called the transition zone is a gate that controls ciliary composition. For example, the transition zone regulates the ciliary localization of Smoothened and, therefore, is required for Hedgehog signaling.
4. They identified many transition zone components and discovered that some ciliopathies are caused by inherited human mutations in these transition zone components.
5. They found a phosphoinositide that marks the ciliary membrane and helps direct which proteins localize to cilia. This was the first identification of a specific cilia-enriched lipid.
6. They investigated how cilia regulate adult tissue homeostasis. Recently, they have shown how cilia of hypothalamic neurons signal to regulate satiety and how cilia restrict adipogenesis.
Education
- Yale College, New Haven, CT, BA, 1989-1993, Molecular Biochemistry and Biophysics
- University of California, San Francisco, PhD, 1995-1999, Genetics
- University of California, San Francisco, MD, 1993-1995, 2000-2001, Medicine
- University of California, Berkeley, Postdoctoral Fellowship, 2001-2003, Developmental Biology
- University of California, San Francisco, UCSF Fellow, 2003-2006, Developmental and Stem Cell Biology Program
Honors & Awards
- 2001
Alpha Omega Alpha Honor Medical Society - 2004
March of Dimes Basil O’Connor Research Award - 2005
Burroughs Wellcome Fund Career Award in the Biomedical Sciences - 2007
Packard Fellow for Science and Engineering - 2009
Presidential Early Career Award for Scientists and Engineers (PECASE) - 2010
American Society for Clinical Investigation (ASCI) - 2011
National Academy of Science Kavli Fellow - 2012
American Association of Anatomists R. R. Bensley Award in Cell Biology - 2015
Grace Boyer Junior Faculty Endowed Chair - 2017
Albert Bowers Endowed Chair - 2017
Achievement Rewards for College Scientists (ARCS) Distinguished Scholar Alumni Award
Selected Publications
- Hasenpusch-Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, Abrams SR, Reiter JF, Schneider-Maunoury S, Theil T. A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. Elife. 2020 Aug 25; 9.
View on PubMed - Hilgendorf KI, Johnson CT, Mezger A, Rice SL, Norris AM, Demeter J, Greenleaf WJ, Reiter JF, Kopinke D, Jackson PK. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019 11 27; 179(6):1289-1305.e21.
View on PubMed - Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2019 06 27; 178(1):261.
View on PubMed - Kodani A, Moyer T, Chen A, Holland A, Walsh CA, Reiter JF. SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL. J Cell Biol. 2019 07 01; 218(7):2185-2197.
View on PubMed - Bansal R, Engle SE, Antonellis PJ, Whitehouse LS, Baucum AJ, Cummins TR, Reiter JF, Berbari NF. Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures. Front Cell Neurosci. 2019; 13:266.
View on PubMed - Shi X, Garcia G, Wang Y, Reiter JF, Huang B. Deformed alignment of super-resolution images for semi-flexible structures. PLoS One. 2019; 14(3):e0212735.
View on PubMed - Raleigh DR, Reiter JF. Misactivation of Hedgehog signaling causes inherited and sporadic cancers. J Clin Invest. 2019 02 01; 129(2):465-475.
View on PubMed - Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. Cilia-Associated Oxysterols Activate Smoothened. Mol Cell. 2018 10 18; 72(2):316-327.e5.
View on PubMed - Park SM, Lim JS, Ramakrishina S, Kim SH, Kim WK, Lee J, Kang HC, Reiter JF, Kim DS, Kim HH, Lee JH. Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination. Neuron. 2018 07 11; 99(1):83-97.e7.
View on PubMed - Garcia G, Raleigh DR, Reiter JF. How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In. Curr Biol. 2018 04 23; 28(8):R421-R434.
View on PubMed - Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018 02; 50(2):180-185.
View on PubMed - Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 12 18; 43(6):744-762.e11.
View on PubMed - Raleigh DR, Choksi PK, Krup AL, Mayer W, Santos N, Reiter JF. Hedgehog signaling drives medulloblastoma growth via CDK6. J Clin Invest. 2018 01 02; 128(1):120-124.
View on PubMed - Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 10 31; 19(11):1379.
View on PubMed - Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Oct; 19(10):1178-1188.
View on PubMed - Kopinke D, Roberson EC, Reiter JF. Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis. Cell. 2017 Jul 13; 170(2):340-351.e12.
View on PubMed - Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol. 2017 Sep; 18(9):533-547.
View on PubMed - Vaisse C, Reiter JF, Berbari NF. Cilia and Obesity. Cold Spring Harb Perspect Biol. 2017 Jul 05; 9(7).
View on PubMed - Garcia-Gonzalo FR, Reiter JF. Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition. Cold Spring Harb Perspect Biol. 2017 Feb 01; 9(2).
View on PubMed - Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2017 01 12; 168(1-2):264-279.e15.
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