University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
A. Hunter Shain, PhD

A. Hunter Shain, PhD

Assistant Professor in Residence, Dept. of Dermatology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Education

University of Illinois, Urbana/Champaign, IL, BS, 05/2006, Biochemistry
Stanford University, Palo Alto, CA PhD 04/2012 Cancer Biology
University of California San Francisco, San Francisco, CA, Postdoctoral Fellow, 09/2017

Professional Experience

  • 2005 - 2005
    Scientific Intern, Pfizer, Chesterfield, MO
  • 2006 - 2012
    Graduate Student, Laboratory of Dr. Jonathan Pollack, Stanford University
  • 2007 - 2008
    Teaching Assistant, Stanford University, Stanford, CA
  • 2012 - 2017
    Postdoctoral Fellow, Laboratory of Dr. Boris Bastian, UCSF
  • 2017 - present
    Assistant Professor, Dept. of Dermatology, UCSF

Honors & Awards

  • 2006
    Graduate Summa Cum Laude, University of Illinois
  • 2006
    William T. & Lynn Jackson Best Senior Thesis Award, University of Illinois
  • 2010
    EACR-21 Presidential Session Speaker and Bursary Award Winner, European Association ofCancer Research
  • 2011
    AACR Scholar-In-Training Award, American Association of Cancer Research
  • 2014
    Helen Diller Family Comprehensive Cancer Retreat Oral Presentation, University of CaliforniaSan Francisco
  • 2015
    SMR Plenary Session Speaker and Travel Award Winner, Society of Melanoma Research
  • 2016
    Helen Diller Family Comprehensive Cancer Retreat Oral Presentation, University of CaliforniaSan Francisco
  • 2016
    AACR Scholar-In-Training Award, American Association of Cancer Research
  • 2017
    Keynote speaker, Ophthalmic Oncology Group Spring Meeting, Rotterdam Netherlands
  • 2017
    SMR Oral Presentation, Society of Melanoma Research

Selected Publications

  1. Shain AH, Bagger MM, Yu R, Chang D, Liu S, Vemula S, Weier JF, Wadt K, Heegaard S, Bastian BC, Kiilgaard JF. The genetic evolution of metastatic uveal melanoma. Nat Genet. 2019 Jul; 51(7):1123-1130.
    View on PubMed
  2. Joseph NM, Tsokos CG, Umetsu SE, Shain AH, Kelley RK, Onodera C, Bowman S, Talevich E, Ferrell LD, Kakar S, Krings G. Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma. J Pathol. 2019 Jan 28.
    View on PubMed
  3. Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM. Targeted genomic profiling of acral melanoma. J Natl Cancer Inst. 2019 Jan 18.
    View on PubMed
  4. Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E, Shain A, Xu M, Lill J, Dixit VM, Bastian BC, Dey A. The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma. Pigment Cell Melanoma Res. 2019 Mar; 32(2):269-279.
    View on PubMed
  5. Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL. Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation. Cancer Cell. 2018 07 09; 34(1):56-68.e9.
    View on PubMed
  6. Shain AH, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC. Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution. Cancer Cell. 2018 07 09; 34(1):45-55.e4.
    View on PubMed
  7. Shain AH, Bastian BC. Filling the gaps in the genomic catalogue of melanoma subtypes. Pigment Cell Melanoma Res. 2017 01; 30(6):508-509.
    View on PubMed
  8. Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A. Combined activation of MAP kinase pathway and ß-catenin signaling cause deep penetrating nevi. Nat Commun. 2017 09 21; 8(1):644.
    View on PubMed
  9. Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D. Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism. Science. 2017 09 29; 357(6358):1416-1420.
    View on PubMed
  10. Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC. NTRK3 kinase fusions in Spitz tumours. J Pathol. 2016 11; 240(3):282-290.
    View on PubMed
  11. Shain AH, Bastian BC. From melanocytes to melanomas. Nat Rev Cancer. 2016 06; 16(6):345-58.
    View on PubMed
  12. Talevich E, Shain AH, Botton T, Bastian BC. CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing. PLoS Comput Biol. 2016 Apr; 12(4):e1004873.
    View on PubMed
  13. Shain AH, Bastian BC. The Genetic Evolution of Melanoma. N Engl J Med. 2016 03 10; 374(10):995-6.
    View on PubMed
  14. Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC. The Genetic Evolution of Melanoma from Precursor Lesions. N Engl J Med. 2015 Nov 12; 373(20):1926-36.
    View on PubMed
  15. Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9.
    View on PubMed
  16. Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC. Activating MET kinase rearrangements in melanoma and Spitz tumours. Nat Commun. 2015 May 27; 6:7174.
    View on PubMed
  17. Shain AH, Salari K, Giacomini CP, Pollack JR. Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics. 2013 Sep 16; 14:624.
    View on PubMed
  18. Giacomini CP, Sun S, Varma S, Shain AH, Giacomini MM, Balagtas J, Sweeney RT, Lai E, Del Vecchio CA, Forster AD, Clarke N, Montgomery KD, Zhu S, Wong AJ, van de Rijn M, West RB, Pollack JR. Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PLoS Genet. 2013 Apr; 9(4):e1003464.
    View on PubMed
  19. Shain AH, Pollack JR. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS One. 2013; 8(1):e55119.
    View on PubMed
  20. Del Vecchio CA, Jensen KC, Nitta RT, Shain AH, Giacomini CP, Wong AJ. Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma. Cancer Res. 2012 May 15; 72(10):2657-71.
    View on PubMed

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