University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Ma Somsouk, MD, MAS

Ma Somsouk, MD, MAS

Assistant Professor, Department of Medicine (Gastroenterology), UCSF

Cancer Center Program Memberships

Cancer Control

Research Summary

1. Leveraging digital health and care coordination to improve health services delivery to vulnerable populations. We embrace big data and technology to design, develop, and deliver economic and effective services for patients in the area of cancer screening and follow-up.

2. Development of intestinal organoids from humans to understand barrier function, systemic inflammation, inflammatory bowel disease, HIV persistence, infection, and microbiome. Approaches employed: organoid models, isolation of epithelial cells, lymphocytes, microbiota, and interventional trials such as fecal transplant.

Education

Pomona College, Claremont, CA, BA, 1993-1997, Chemistry
Harvard Medical School, Boston, MA, MD, 1997-2002, Medicine
Harbor-UCLA Medical Center, Torrance, CA, Residency, 2002-2005, Internal Medicine
University of California, San Francisco, CA, Fellowship, 2005-2008, Gastroenterology
University of California, San Francisco, CA, MAS, 2006-2008, Epidemiology and Biostatistics


Professional Experience

  • 2001-2002
    Research Scholar at Beijing University Health Science Center, China
  • 2002-2003
    Internship in Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA
  • 2003-2005
    Residency in Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA
  • 2005-2008
    Gastroenterology Fellowship, UCSF, San Francisco, CA
  • 2008-present
    Assistant Adjunct Professor of Medicine, UCSF, San Francisco, CA
  • 2009-present
    Director, Gastrointestinal Tissue Core Facility, UCSF, San Francisco, CA

Honors & Awards

  • 1997
    Sigma Xi
  • 1997
    Phi Beta Kappa
  • 1997
    Magna Cum Laude
  • 2000
    China Scholarship Council Research Scholar Fellowship
  • 2000
    Paul Dudley White/Andrew Sellard Fellowship
  • 2003
    Solomon Scholar
  • 2003
    AASLD Resident Scholar Award
  • 2006
    AGA Trainee Scholarship: Methodologies in Healthcare Outcomes in Gastroenterology
  • 2008
    AGA Academic Skills Workshop Scholarship

Selected Publications

  1. Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S. The impact of antiretroviral therapy duration on the HIV-1 infection of T-cells within anatomic sites. J Virol. 2019 Nov 13.
    View on PubMed
  2. Sangaramoorthy M, Yang J, DeRouen MC, Ho C, Somsouk M, Tana MM, Thompson CA, Gibbons J, Gomez SL, Shariff-Marco S. Disparities in Hepatocellular Carcinoma Incidence in California: An Update. Cancer Epidemiol Biomarkers Prev. 2019 Nov 12.
    View on PubMed
  3. Belle NM, Ji Y, Herbine K, Wei Y, Park J, Zullo K, Hung LY, Srivatsa S, Young T, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR. TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths. Nat Commun. 2019 Sep 27; 10(1):4408.
    View on PubMed
  4. Selvig D, Piceno Y, Terdiman J, Zydek M, Umetsu SE, Balitzer D, Fadrosh D, Lynch K, Lamere B, Leith T, Kassam Z, Beck K, Lewin S, Ma A, Somsouk M, Lynch SV, El-Nachef N. Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study. Dig Dis Sci. 2019 Jul 13.
    View on PubMed
  5. Somsouk M, Rachocki C, Mannalithara A, Garcia D, Laleau V, Grimes B, Issaka RB, Chen E, Vittinghoff E, Shapiro JA, Ladabaum U. Effectiveness and cost of organized outreach for colorectal cancer screening: A Randomized Controlled Trial. J Natl Cancer Inst. 2019 Jun 12.
    View on PubMed
  6. Vujkovic-Cvijin I, Somsouk M. HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration. Curr HIV/AIDS Rep. 2019 Jun; 16(3):204-213.
    View on PubMed
  7. Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ. CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals. Pathog Immun. 2019; 4(1):147-160.
    View on PubMed
  8. Utay NS, Somasunderam A, Hinkle JE, Petschow BW, Detzel CJ, Somsouk M, Fichtenbaum CJ, Weaver EM, Shaw AL, Asmuth DM. Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART. Pathog Immun. 2019; 4(1):124-146.
    View on PubMed
  9. Gutin L, Piceno Y, Fadrosh D, Lynch K, Zydek M, Kassam Z, LaMere B, Terdiman J, Ma A, Somsouk M, Lynch S, El-Nachef N. Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile. United European Gastroenterol J. 2019 Jul; 7(6):807-814.
    View on PubMed
  10. Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection. PLoS Pathog. 2019 04; 15(4):e1007672.
    View on PubMed
  11. Maidji E, Moreno ME, Rivera JM, Joshi P, Galkina SA, Kosikova G, Somsouk M, Stoddart CA. Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice. Viruses. 2019 03 13; 11(3).
    View on PubMed
  12. Wang A, Rachocki C, Shapiro JA, Issaka RB, Somsouk M. Low Literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples. Clin Gastroenterol Hepatol. 2019 Aug; 17(9):1822-1828.
    View on PubMed
  13. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS Pathog. 2018 11; 14(11):e1007357.
    View on PubMed
  14. Issaka RB, Avila P, Whitaker E, Bent S, Somsouk M. Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review. Prev Med. 2019 01; 118:113-121.
    View on PubMed
  15. Lidofsky A, Holmes JA, Feeney ER, Kruger AJ, Salloum S, Zheng H, Seguin IS, Altinbas A, Masia R, Corey KE, Gustafson JL, Schaefer EA, Hunt PW, Deeks S, Somsouk M, Chew KW, Chung RT, Alatrakchi N. Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection. J Infect Dis. 2018 09 22; 218(9):1394-1403.
    View on PubMed
  16. Ellis L, Abrahão R, McKinley M, Yang J, Somsouk M, Marchand LL, Cheng I, Gomez SL, Shariff-Marco S. Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014. Cancer Epidemiol Biomarkers Prev. 2018 09; 27(9):1011-1018.
    View on PubMed
  17. Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM. Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved. Autoimmunity. 2018 08; 51(5):258-264.
    View on PubMed
  18. Alsayid M, Singh MH, Issaka R, Laleau V, Day L, Lee J, Allison J, Somsouk M. Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light. Clin Gastroenterol Hepatol. 2018 10; 16(10):1593-1597.e1.
    View on PubMed
  19. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018 03; 14(3):e1006806.
    View on PubMed
  20. Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ. Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. PLoS Pathog. 2018 02; 14(2):e1006856.
    View on PubMed

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