University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Yerem Yeghiazarians, MD

Yerem Yeghiazarians, MD

Professor of Medicine, UCSF
Leone-Perkins Family Endowed Chair in Cardiology

Cancer Center Program Memberships

Experimental Therapeutics

Research Summary

CLINICAL INTERESTS: Dr. Yerem Yeghiazarians is an interventional cardiologist with expertise in managing patients with coronary artery disease, acute coronary syndromes, valvular heart disease, cardiomyopathies, patent foramen ovale, and peripheral arterial diseases. Yeghiazarians earned an undergraduate degree from Brandeis University and a medical degree from the Johns Hopkins School of Medicine. He trained in internal medicine at Brigham and Women's Hospital, Harvard Medical School, where he served as chief medical resident and instructor in medicine. He also completed general and interventional adult cardiology training at the Brigham and Women's Hospital. He has been at UCSF since 2003.

RESEARCH INTERESTS: Dr. Yeghiazarians is the Director of the Translational Cardiac Stem Cell Porgram at UCSF. His research interests are to study the role of stem cells in improving the cardiac function after a myocardial infarction.

Education

  • Brandeis University, Waltham, MA, B.A., 1991, Biochemistry/Biology
  • Johns Hopkins School of Medicine, Baltimore, MD, M.D., 1995, Medicine
  • Brigham and Women’s Hospital/Harvard Medical School, 1995-1998, Intern/Resident, Internal Medicine
  • Brigham and Women’s Hospital/Harvard Medical School, 2000-2001, Chief Resident, Internal Medicine
  • Brigham and Women’s Hospital/Harvard Medical School, 1998-2003, Cardiology/Interventional Fellow

Professional Experience

  • 2000-2001
    Chief Medical Resident, Department of Medicine, Brigham andWomen’s Hospital, Harvard Medical School
  • 2003-2009
    Assistant Professor of Medicine, University of California, San Francisco
  • 2009-6/2015
    Associate Professor of Medicine, University of California, San Francisco
  • 7/2015-present
    Professor of Medicine, University of California, San Francisco
  • 2003-present
    Director, Translational Cardiac Stem Cell Program, UCSF
  • 2006-present
    Co-Director, Cardiac Catheterization Laboratory, UCSF
  • 2006-present
    Director, Peripheral Interventional Cardiology Program, UCSF
  • 2011-present
    Leone-Perkins Family Endowed Chair in Cardiology

Selected Publications

  1. Papolos A, Fan E, Wagle RR, Foster E, Boyle AJ, Yeghiazarians Y, MacGregor JS, Grossman W, Schiller NB, Ganz P, Tison GH. Echocardiographic determination of pulmonary arterial capacitance. Int J Cardiovasc Imaging. 2019 Sep; 35(9):1581-1586.
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  2. Tietjens JR, Claman D, Kezirian EJ, De Marco T, Mirzayan A, Sadroonri B, Goldberg AN, Long C, Gerstenfeld EP, Yeghiazarians Y. Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy. J Am Heart Assoc. 2019 01 08; 8(1):e010440.
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  3. Browne S, Jha AK, Ameri K, Marcus SG, Yeghiazarians Y, Healy KE. TGF-ß1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels. PLoS One. 2018; 13(3):e0194679.
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  4. Geng X, Hwang J, Ye J, Shih H, Coulter B, Naudin C, Jun K, Sievers R, Yeghiazarians Y, Lee RJ, Boyle AJ. Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling. Am J Cardiovasc Dis. 2017; 7(3):72-82.
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  5. Ameri K, Samurkashian R, Yeghiazarians Y. Three-Dimensional Bioprinting: Emerging Technology in Cardiovascular Medicine. Circulation. 2017 04 04; 135(14):1281-1283.
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  6. Kallianos K, Henry TS, Yeghiazarians Y, Zimmet J, Shunk KA, Tseng EE, Mahadevan V, Hope MD. Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency. Int J Cardiol. 2017 Mar 15; 231:255-257.
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  7. Jha AK, Tharp KM, Browne S, Ye J, Stahl A, Yeghiazarians Y, Healy KE. Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials. 2016 May; 89:136-47.
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  8. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. J Am Heart Assoc. 2016 Jan 06; 5(1).
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  9. Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT. Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation. J Nucl Cardiol. 2017 02; 24(1):268-277.
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  10. Ye J, Yeghiazarians Y. Cardiac stem cell therapy: Have we put too much hype in which cell type to use? Heart Fail Rev. 2015 Sep; 20(5):613-9.
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  11. Ye J, Gaur M, Zhang Y, Sievers RE, Woods BJ, Aurigui J, Bernstein HS, Yeghiazarians Y. Treatment with hESC-Derived Myocardial Precursors Improves Cardiac Function after a Myocardial Infarction. PLoS One. 2015; 10(7):e0131123.
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  12. Genet M, Chuan Lee L, Ge L, Acevedo-Bolton G, Jeung N, Martin A, Cambronero N, Boyle A, Yeghiazarians Y, Kozerke S, Guccione JM. A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging. J Biomech Eng. 2015 Aug; 137(8):081009.
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  13. Jha AK, Mathur A, Svedlund FL, Ye J, Yeghiazarians Y, Healy KE. Molecular weight and concentration of heparin in hyaluronic acid-based matrices modulates growth factor retention kinetics and stem cell fate. J Control Release. 2015 Jul 10; 209:308-16.
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  14. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 17; 10(6):891-899.
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  15. Jha AK, Tharp KM, Ye J, Santiago-Ortiz JL, Jackson WM, Stahl A, Schaffer DV, Yeghiazarians Y, Healy KE. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials. 2015 Apr; 47:1-12.
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  16. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. Cardiac steatosis potentiates angiotensin II effects in the heart. Am J Physiol Heart Circ Physiol. 2015 Feb 15; 308(4):H339-50.
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  17. Shrestha U, Botvinick EH, Yeghiazarians Y, Seo Y, Gullberg GT. Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT. IEEE Nucl Sci Symp Conf Rec (1997). 2014 Nov; 2014.
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  18. Feng K, Gupta V, Terrazas E, Yeghiazarians Y, Ports T, Gregoratos G, Tavakol M, Roberts JP, Boyle A. Trans-radial versus trans-femoral access in patients with end-stage liver disease undergoing cardiac catheterization. Am J Cardiovasc Dis. 2014; 4(3):133-9.
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  19. Gupta V, Feng K, Cheruvu P, Boyer N, Yeghiazarians Y, Ports TA, Zimmet J, Shunk K, Boyle AJ. High femoral artery bifurcation predicts contralateral high bifurcation: implications for complex percutaneous cardiovascular procedures requiring large caliber and/or dual access. J Invasive Cardiol. 2014 Sep; 26(9):409-12.
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  20. Pandit J, Gupta V, Boyer N, Yeghiazarians Y, Ports TA, Boyle AJ. Patient and physician perspectives on outcomes weighting in revascularization. The POWR study. Int J Cardiol. 2014 Dec 15; 177(2):513-4.
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