Research Summary

I am a dermatopathologist with a PhD in Biomedical Informatics. I maintain an active academic clinical dermatopathology practice with a specialization in the diagnosis of melanocytic tumors and lead a basic and translational research laboratory focused on the genetics and biology of melanocytic tumors and the use of molecular assessments to improve diagnosis. Our multi-disciplinary team works on identifying and characterizing novel oncogenes and tumor suppressors in melanocytic neoplasia and understanding their biology.

Education

Harvard College, AB 1994-1997, Biochemical Sciences
Stanford University Medical School, MD, PhD 1998-2006, Medicine and Biomedical Informatics
Santa Clara Valley Medical Center, 2006-2007, Internship
University of Washington, 2007-2010, Dermatology Residency
University of California, San Francisco, 2010-2011, Dermatopathology Fellowship

Honors & Awards

  • 1997
    Phi Beta Kappa, Harvard College Chapter, Cambridge, MA
  • 1998
    Medical Scientist Training Program, Predoctoral Fellowship, National Institutes of Health
  • 2003
    Graduate Fellowship, National Library of Medicine
  • 2006
    Doctoral Commencement Speaker, Stanford Medical School
  • 2014
    American Cancer Society Individual Research Award
  • 2014
    Melanoma Research Alliance Career Development Award
  • 2014
    Dermatology Foundation Career Development Award
  • 2014
    Melanoma Research Foundation Mucosal Melanoma Career Development Award
  • 2020
    Stiefel Scholar Award in Skin Cancer

Selected Publications

  1. Martin SB, Polubothu S, Bruzos AL, Kelly G, Horswell S, Sauvadet A, Bryant D, Zecchin D, Riachi M, Michailidis F, Sadri A, Muwanga-Nanyonjo N, Lopez-Balboa P, Knöpfel N, Bulstrode N, Pittman A, Yeh I, Kinsler V. Mosaic BRAF fusions are a recurrent cause of congenital melanocytic naevi targetable by MEK inhibition. J Invest Dermatol. 2023 Sep 14.  View on PubMed
  2. Perkins IU, Tan SY, McCalmont TH, Chou PM, Mully TW, Gerami P, Pomerantz JH, Reyes-Múgica M, Balkin DM, Kruse LL, Huang B, Reichek JL, Gangopadhyay N, Chiosea S, Green JR, Chamlin SL, Frieden IJ, Bastian BC, Yeh I. Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK). Pigment Cell Melanoma Res. 2024 01; 37(1):6-14.  View on PubMed
  3. de la Fouchardière A, Pissaloux D, Houlier A, Paindavoine S, Tirode F, LeBoit PE, Bastian BC, Yeh I. Histologic and Genetic Features of 51 Melanocytic Neoplasms With Protein Kinase C Fusion Genes. Mod Pathol. 2023 Nov; 36(11):100286.  View on PubMed
  4. Lorbeer FK, Rieser G, Goel A, Wang M, Oh A, Yeh I, Bastian BC, Hockemeyer D. Distinct senescence mechanisms restrain progression of dysplastic nevi. bioRxiv. 2023 Jul 16.  View on PubMed
  5. Roy SF, Milante R, Pissaloux D, Tirode F, Bastian BC, Fouchardière A, Yeh I. Spectrum of Melanocytic Tumors Harboring BRAF Gene Fusions: 58 Cases With Histomorphologic and Genetic Correlations. Mod Pathol. 2023 06; 36(6):100149.  View on PubMed
  6. Lezcano C, Berwick M, Luo L, Barnhill R, Duncan LM, Gerami P, Lowe L, Messina JL, Scolyer RA, Wood B, Yeh I, Zembowicz A, Busam KJ. Interobserver agreement in the histopathological classification of desmoplastic melanomas. Pathology. 2023 Mar; 55(2):223-226.  View on PubMed
  7. Yeh I. Melanocytic naevi, melanocytomas and emerging concepts. Pathology. 2023 Mar; 55(2):178-186.  View on PubMed
  8. Wang M, Banik I, Shain AH, Yeh I, Bastian BC. Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes. Genome Med. 2022 06 16; 14(1):65.  View on PubMed
  9. Jiang H, Muir RK, Gonciarz RL, Olshen AB, Yeh I, Hann BC, Zhao N, Wang YH, Behr SC, Korkola JE, Evans MJ, Collisson EA, Renslo AR. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. J Exp Med. 2022 04 04; 219(4).  View on PubMed
  10. Yeh I. Update on classification of melanocytic tumors and the role of immunohistochemistry and molecular techniques. Semin Diagn Pathol. 2022 Jul; 39(4):248-256.  View on PubMed
  11. Chen JY, Keiser E, LeBoit P, Yeh I, Wei ML. A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa. JAAD Case Rep. 2022 Mar; 21:49-51.  View on PubMed
  12. Yeh I, Busam KJ. Spitz melanocytic tumours - a review. Histopathology. 2022 Jan; 80(1):122-134.  View on PubMed
  13. Benton S, Zhao J, Zhang B, Bahrami A, Barnhill RL, Busam K, Cerroni L, Cook MG, de la Fouchardière A, Elder DE, Johansson I, Landman G, Lazar A, LeBoit P, Lowe L, Massi D, Duncan LM, Messina J, Mihic-Probst D, Mihm MC, Piepkorn MW, Schmidt B, Scolyer RA, Shea CR, Tetzlaff MT, Tron VA, Xu X, Yeh I, Yun SJ, Zembowicz A, Gerami P. Impact of Next-generation Sequencing on Interobserver Agreement and Diagnosis of Spitzoid Neoplasms. Am J Surg Pathol. 2021 12 01; 45(12):1597-1605.  View on PubMed
  14. Sheahon KM, Jankowski T, Yeh I, North JP, Pincus LB, LeBoit PE, McCalmont TH, Lang UE. Primary Cilia Are Preserved in Cellular Blue and Atypical Blue Nevi and Lost in Blue Nevus-like Melanoma. Am J Surg Pathol. 2021 09 01; 45(9):1205-1212.  View on PubMed
  15. Robertson SJ, Orme L, Teixeira R, Shamassi M, Newell F, Patch AM, Yeh I, Gard G, Wilmott J, Jackett L, LeBoit P, Fellowes A, MacArthur G, Fox S, Hayward NK, Bastian B, Scolyer R, Waddell N, Penington A, Shackleton M. Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi. JAMA Dermatol. 2021 Jul 01; 157(7):836-841.  View on PubMed
  16. Gu W, Talevich E, Hsu E, Qi Z, Urisman A, Federman S, Gopez A, Arevalo S, Gottschall M, Liao L, Tung J, Chen L, Lim H, Ho C, Kasowski M, Oak J, Holmes BJ, Yeh I, Yu J, Wang L, Miller S, DeRisi JL, Prakash S, Simko J, Chiu CY. Detection of cryptogenic malignancies from metagenomic whole genome sequencing of body fluids. Genome Med. 2021 06 01; 13(1):98.  View on PubMed
  17. Cohen JN, Yeh I, Mully TW, LeBoit PE, McCalmont TH. Response To: Feasibility of a Tumor Progression Model in PRKAR1A-inactivated Melanomas. Am J Surg Pathol. 2021 06 01; 45(6):869-870.  View on PubMed
  18. Yeh I, Bastian BC. Melanoma pathology: new approaches and classification. Br J Dermatol. 2021 08; 185(2):282-293.  View on PubMed
  19. Roy SF, Bastian BC, Maguiness S, Giubellino A, Vemula SS, McCalmont TH, Yeh I. Multiple desmoplastic Spitz nevi with BRAF fusions in a patient with ring chromosome 7 syndrome. Pigment Cell Melanoma Res. 2021 09; 34(5):987-993.  View on PubMed
  20. Chenbhanich J, Hu Y, Hetts S, Cooke D, Dowd C, Devine P, UCLA Clinical Genomics Center, Russell B, Kang SHL, Chang VY, Abla AA, Cornett P, Yeh I, Lee H, Martinez-Agosto JA, Frieden IJ, Shieh JT. Segmental overgrowth and aneurysms due to mosaic PDGFRB p.(Tyr562Cys). Am J Med Genet A. 2021 05; 185(5):1430-1436.  View on PubMed

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