University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Sue S. Yom, MD, PhD

Sue S. Yom, MD, PhD

Professor, Department of Radiation Oncology, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Research Summary

My primary clinical and research interests include head and neck, thoracic, and cutaneous malignancies, where I have developed and led multiple clinical trials, both within UCSF and across sites nationwide and overseas. I am interested in the development and evaluation of new therapeutic techniques, which to me include novel molecular targeted agents and immunotherapies as well as state-of-the-art technical advances in radiation therapy. I have special interests in virally driven malignancies associated with humanpapillomavirus (HPV), Epstein-Barr virus (EBV), and Merkel cell polyomavirus. My research has entailed collaborating with laboratory-based investigators to identify patient, tumor, and technical characteristics that influence prognosis and response to specific therapies, including tissue-, blood-, and imaging-based biomarkers. Other university responsibilities include co-leading the site committees for clinical trial development in cutaneous and head and neck cancers at the UCSF HDFCCC and serving on the Cancer Committee which maintains our accreditation through the American College of Surgeons. Nationally, I have served as the chair of the scientific program and nominating committees for the American Radium Society (ARS), chair of the Appropriateness Committee guidelines for radiation oncology at the American College of Radiology (ACR), and head and neck senior editor at the International Journal for Radiation Oncology Biology Physics (IJROBP). I have been on the scientific program committees of the American Society for Radiation Oncology (ASTRO), the International Association for the Study of Lung Cancer (IASLC), and the American Head and Neck Society (AHNS). I am a member of the NRG Oncology Head and Neck Steering Committee, NCI’s Head and Neck Recurrent/Metastatic Disease Task Force, and the NCCN Head and Neck Cancers guidelines committee. I am a national boards examiner for the American Board of Radiology.

Education

2002, University of Pennsylvania, Philadelphia, PA, M.D., Ph.D., Medicine/English
2003, U. T. – M. D. Anderson Cancer Center, Internship, Medicine/Surgery
2007, U. T. – M. D. Anderson Cancer Center, Residency, Radiation Oncology


Professional Experience

  • 2007-2013
    Assistant Professor of Clinical Radiation Oncology, University of California, San Francisco
  • 2007-present
    Consultant in Radiology, San Francisco Veterans Administration Medical Center
  • 2008-2013
    Assistant Professor in Otolaryngology-Head and Neck Surgery, by courtesy
  • 2013-present
    Professor of Clinical Radiation Oncology, University of California, San Francisco
  • 2013-present
    Professor in Otolaryngology-Head and Neck Surgery, by courtesy

Honors & Awards

  • 1992
    Mellon Fellow in the Humanities, Andrew W. Mellon Foundation
  • 1995
    Benjamin Franklin Medical Scholar Fellowship, University of Pennsylvania
  • 2004
    Thomas Barkley Award, M. D. Anderson Cancer Center
  • 2005
    Fellowship, Korean American Society for Therapeutic Radiology & Oncology
  • 2006
    Jesse H. Jones Fellowship in Cancer Education, M. D. Anderson Cancer Center
  • 2006
    Outstanding Resident Presentation Award, Texas Radiological Society
  • 2006
    A. Lavoy Moore Endowment Fund, M. D. Anderson Cancer Center
  • 2006
    Eleanor Montague Distinguished Resident Award, American Association of Women Radiologists
  • 2008
    Joan F. Giambalvo Memorial Scholarship, AMA Women Physicians Congress
  • 2009
    Best Doctors in America, 2009-2014
  • 2011
    Educator of the Year Award, Association of Residents in Radiation Oncology

Selected Publications

  1. Guckenberger M, Belka C, Bezjak A, Bradley J, Daly ME, DeRuysscher D, Dziadziuszko R, Faivre-Finn C, Flentje M, Gore E, Higgins KA, Iyengar P, Kavanagh BD, Kumar S, Le Pechoux C, Lievens Y, Lindberg K, McDonald F, Ramella S, Rengan R, Ricardi U, Rimner A, Rodrigues GB, Schild SE, Senan S, Simone Ii CB, Slotman BJ, Stuschke M, Videtic G, Widder J, Yom SS, Palma D. Practice Recommendations for Lung Cancer Radiotherapy During the COVID-19 Pandemic: An ESTRO-ASTRO Consensus Statement. Int J Radiat Oncol Biol Phys. 2020 07 15; 107(4):631-640.
    View on PubMed
  2. Park S, Vora M, van Zante A, Humtsoe J, Kim HS, Yom S, Agarwal S, Ha P. Clinicopathologic implications of Myb and Beta-catenin expression in adenoid cystic carcinoma. J Otolaryngol Head Neck Surg. 2020 Jul 10; 49(1):48.
    View on PubMed
  3. Kearney V, Chan JW, Wang T, Perry A, Descovich M, Morin O, Yom SS, Solberg TD. DoseGAN: a generative adversarial network for synthetic dose prediction using attention-gated discrimination and generation. Sci Rep. 2020 Jul 06; 10(1):11073.
    View on PubMed
  4. Vasudevan HN, Yom SS. Combining Systemic Therapy With Radiation: Head and Neck Cancer Treatments in an Era of Targeted Agents and Immunotherapy. J Natl Compr Canc Netw. 2020 Jul; 18(7):907-913.
    View on PubMed
  5. Pfister DG, Spencer S, Adelstein D, Adkins D, Anzai Y, Brizel DM, Bruce JY, Busse PM, Caudell JJ, Cmelak AJ, Colevas AD, Eisele DW, Fenton M, Foote RL, Galloway T, Gillison ML, Haddad RI, Hicks WL, Hitchcock YJ, Jimeno A, Leizman D, Maghami E, Mell LK, Mittal BB, Pinto HA, Ridge JA, Rocco JW, Rodriguez CP, Shah JP, Weber RS, Weinstein G, Witek M, Worden F, Yom SS, Zhen W, Burns JL, Darlow SD. Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020 Jul; 18(7):873-898.
    View on PubMed
  6. Foster CC, Fan M, Lee NY, Yom SS, Heaton CM, Deraniyagala R, Amdur R, Weichselbaum RR, Haraf DJ. Is It Worth It? Consequences of Definitive Head and Neck Reirradiation. Semin Radiat Oncol. 2020 Jul; 30(3):212-217.
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  7. Flavell RR, Evans MJ, Villanueva-Meyer JE, Yom SS. Understanding response to immunotherapy using standard of care and experimental imaging approaches. Int J Radiat Oncol Biol Phys. 2020 Jun 22.
    View on PubMed
  8. Mehanna H, Hardman JC, Shenson JA, Abou-Foul AK, Topf MC, AlFalasi M, Chan JYK, Chaturvedi P, Chow VLY, Dietz A, Fagan JJ, Godballe C, Golusinski W, Homma A, Hosal S, Iyer NG, Kerawala C, Koh YW, Konney A, Kowalski LP, Kraus D, Kuriakose MA, Kyrodimos E, Lai SY, Leemans CR, Lennon P, Licitra L, Lou PJ, Lyons B, Mirghani H, Nichols AC, Paleri V, Panizza BJ, Parente Arias P, Patel MR, Piazza C, Rischin D, Sanabria A, Takes RP, Thomson DJ, Uppaluri R, Wang Y, Yom SS, Zhu YM, Porceddu SV, de Almeida JR, Simon C, Holsinger FC. Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus. Lancet Oncol. 2020 Jul; 21(7):e350-e359.
    View on PubMed
  9. Rosen EB, Ahmed ZU, Randazzo JD, Yom S, Estilo CL, Huryn JM. Dental intervention for the irradiated patient: time to re-evaluate dental treatment algorithms? Br J Oral Maxillofac Surg. 2020 May 28.
    View on PubMed
  10. Thomson DJ, Yom SS. In Reply to Gupta et al. Int J Radiat Oncol Biol Phys. 2020 Jul 15; 107(4):854.
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  11. Chang CF, Ei-Sayed IH, George JR, Heaton CM, Ryan WR, Susko MS, Yom SS, Ha PK. Modified technique of submandibular gland transfer followed by intensity modulated radiotherapy to reduce xerostomia in head and neck cancer patients. Head Neck. 2020 May 13.
    View on PubMed
  12. Thomson DJ, Yom SS. On the Question of Resource Constraints During the COVID-19 Pandemic, Thinking Globally. Int J Radiat Oncol Biol Phys. 2020 May 13.
    View on PubMed
  13. Susko MS, Lazar AA, Dhar S, Chan JW, Shiao SL, Chapman CH, Johnson J, Quivey JM, Ryan WR, Heaton CM, Ha PK, Yom SS. Improved Tumor Control Related to Radiotherapy Technological Development for Hypopharyngeal Cancer. Laryngoscope. 2020 May 12.
    View on PubMed
  14. Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, Brizel D, Budach W, Caudell J, Corry J, Corvo R, Evans M, Garden AS, Giralt J, Gregoire V, Harari PM, Harrington K, Hitchcock YJ, Johansen J, Kaanders J, Koyfman S, Langendijk JA, Le QT, Lee N, Margalit D, Mierzwa M, Porceddu S, Soong YL, Sun Y, Thariat J, Waldron J, Yom SS. Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement. Int J Radiat Oncol Biol Phys. 2020 07 15; 107(4):618-627.
    View on PubMed
  15. Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT. Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN). Int J Radiat Oncol Biol Phys. 2020 Jul 15; 107(4):641-651.
    View on PubMed
  16. Guckenberger M, Belka C, Bezjak A, Bradley J, Daly ME, DeRuysscher D, Dziadziuszko R, Faivre-Finn C, Flentje M, Gore E, Higgins KA, Iyengar P, Kavanagh BD, Kumar S, Le Pechoux C, Lievens Y, Lindberg K, McDonald F, Ramella S, Rengan R, Ricardi U, Rimner A, Rodrigues GB, Schild SE, Senan S, Simone CB 2nd, Slotman BJ, Stuschke M, Videtic G, Widder J, Yom SS, Palma D. Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement. Radiother Oncol. 2020 05; 146:223-229.
    View on PubMed
  17. Almutuawa DM, Strohl MP, Gruss C, van Zante A, Yom SS, McDermott MW, El-Sayed IH. Outcomes of sinonasal mucosal melanomas with endoscopic and open resection: a retrospective cohort study. J Neurooncol. 2020 Mar 29.
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  18. Grégoire V, Grau C, Le QT, Yom SS. Comments on the Publication by Corkum et al on "Does 5 + 5 mm Equal Better Radiation Treatment Plans in Head and Neck Cancers?" Adv Radiat Oncol. 2020 Jan-Feb; 5(1):140-141.
    View on PubMed
  19. Hohenstein NA, Chan JW, Wu SY, Tahir P, Yom SS. Diagnosis, Staging, Radiation Treatment Response Assessment, and Outcome Prognostication of Head and Neck Cancers Using PET Imaging: A Systematic Review. PET Clin. 2020 Jan; 15(1):65-75.
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  20. Wu SY, Yom SS. Current Standards for Organ Preservation in Locoregionally Advanced Non-nasopharyngeal Head and Neck Cancer and Evolving Strategies for Favorable-Risk and Platinum-Ineligible Populations. Curr Treat Options Oncol. 2019 12 04; 20(12):89.
    View on PubMed

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