Research Summary

Jaehoon Shin, MD, PhD, is an Assistant Professor In Residence in the Interventional Radiology section in the Department of Radiology and Biomedical Imaging.

Dr. Shin earned his MD at Seoul National University, South Korea in 2008, followed by a PhD at Johns Hopkins University in 2016. His clinical training includes an internship year at MedStar Harbor Hospital in Baltimore followed by a diagnostic radiology residency with early specialization in interventional radiology (ESIR) at UCSF. In 2022, Dr. Shin completed an interventional radiology fellowship, also at UCSF.

Dr. Shin received the prestigious Samsung Scholarship for doctoral study, and was awarded Best Case in Neuroradiology at the 2019 American Institute for Radiologic Pathology. Dr. Shin is a collaborator on a Medical Research Award from the Robert J. & Helen C. Kleberg Foundation, and principal investigator for a Society for Interventional Radiology Pilot Research Grant. Dr. Shin’s research addresses novel T cell-based imaging (synNotch-PET), which has the potential to detect early cancers and pre-cancerous lesions. Additional research projects include locoregional T cell therapy to enhance treatments for pancreatic cancer and glioblastoma and single-cell RNA sequencing to better understand venous insufficiency and druggable target biological processes.

Education

  • University of California, San Francisco, Fellow, 07/2021 06/2022, Interventional Radiology
  • University of California, San Francisco, Resident, 07/2017 06/2021, Radiology
  • MedStar Harbor Hospital, Baltimore, Maryland, Resident, 06/2016 06/2017, Internship
  • Johns Hopkins Medicine, Baltimore, Maryland, Doctor of Philosophy (PHD), 06/2010 03/2016, Genomics/Stem Cell
  • Seoul National University, Seoul, South Kores, Doctor of Medicine (MD), 03/2004 02/2008, Medicine
  • Seoul National University, Seoul, South Korea, Bachelor of Engineering (BENG), 03/2000 02/2004, Chemical Engineering

Selected Publications

  1. Shin J, Parker MFL, Zhu I, Alanizi A, Rodriguez CI, Liu R, Watchmaker PB, Kalita M, Blecha J, Luu J, Wright B, Lapi SE, Flavell RR, Okada H, Tlsty TD, Roybal KT, Wilson DM. Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma. J Nucl Med. 2023 01; 64(1):137-144. View on PubMed
  2. Lawhn-Heath C, Hope TA, Martinez J, Fung EK, Shin J, Seo Y, Flavell RR. Dosimetry in radionuclide therapy: the clinical role of measuring radiation dose. Lancet Oncol. 2022 02; 23(2):e75-e87. View on PubMed
  3. Shao M, Han S, Carass A, Li X, Blitz AM, Shin J, Prince JL, Ellingsen LM. Brain ventricle parcellation using a deep neural network: Application to patients with ventriculomegaly. Neuroimage Clin. 2019; 23:101871. View on PubMed
  4. Beckervordersandforth R, Ebert B, Schäffner I, Moss J, Fiebig C, Shin J, Moore DL, Ghosh L, Trinchero MF, Stockburger C, Friedland K, Steib K, von Wittgenstein J, Keiner S, Redecker C, Hölter SM, Xiang W, Wurst W, Jagasia R, Schinder AF, Ming GL, Toni N, Jessberger S, Song H, Lie DC. Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Neuron. 2017 03 22; 93(6):1518. View on PubMed
  5. Su Y, Shin J, Zhong C, Wang S, Roychowdhury P, Lim J, Kim D, Ming GL, Song H. Neuronal activity modifies the chromatin accessibility landscape in the adult brain. Nat Neurosci. 2017 Mar; 20(3):476-483. View on PubMed
  6. Beckervordersandforth R, Ebert B, Schäffner I, Moss J, Fiebig C, Shin J, Moore DL, Ghosh L, Trinchero MF, Stockburger C, Friedland K, Steib K, von Wittgenstein J, Keiner S, Redecker C, Hölter SM, Xiang W, Wurst W, Jagasia R, Schinder AF, Ming GL, Toni N, Jessberger S, Song H, Lie DC. Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Neuron. 2017 Feb 08; 93(3):560-573.e6. View on PubMed
  7. Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM, Christian KM, Didier RA, Jin P, Song H, Ming GL. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016 05 05; 18(5):587-90. View on PubMed
  8. Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming GL, Jin P, Song H. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Mol Cell. 2016 Jan 07; 61(1):153-60. View on PubMed
  9. Shin J, Berg DA, Zhu Y, Shin JY, Song J, Bonaguidi MA, Enikolopov G, Nauen DW, Christian KM, Ming GL, Song H. Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis. Cell Stem Cell. 2015 Sep 03; 17(3):360-72. View on PubMed
  10. Yu H, Su Y, Shin J, Zhong C, Guo JU, Weng YL, Gao F, Geschwind DH, Coppola G, Ming GL, Song H. Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nat Neurosci. 2015 Jun; 18(6):836-43. View on PubMed
  11. Shin J, Ming GL, Song H. Seeking a roadmap toward neuroepigenetics. Neuron. 2015 Apr 08; 86(1):12-5. View on PubMed
  12. Shin J, Ming GL, Song H. Molecular toggle switch of histone demethylase LSD1. Mol Cell. 2015 Mar 19; 57(6):949-950. View on PubMed
  13. Shin J, Ming GL, Song H. Decoding neural transcriptomes and epigenomes via high-throughput sequencing. Nat Neurosci. 2014 Nov; 17(11):1463-75. View on PubMed
  14. Shin J, Ming GL, Song H. DNA modifications in the mammalian brain. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26; 369(1652). View on PubMed
  15. Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y, Kim NS, Yoon KJ, Shin J, Zhang C, Makri G, Nauen D, Yu H, Guzman E, Chiang CH, Yoritomo N, Kaibuchi K, Zou J, Christian KM, Cheng L, Ross CA, Margolis RL, Chen G, Kosik KS, Song H, Ming GL. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature. 2014 Nov 20; 515(7527):414-8. View on PubMed
  16. Guo JU, Su Y, Shin JH, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming GL, Song H. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat Neurosci. 2014 Feb; 17(2):215-22. View on PubMed
  17. Weng YL, An R, Shin J, Song H, Ming GL. DNA modifications and neurological disorders. Neurotherapeutics. 2013 Oct; 10(4):556-67. View on PubMed
  18. Hu S, Wan J, Su Y, Song Q, Zeng Y, Nguyen HN, Shin J, Cox E, Rho HS, Woodard C, Xia S, Liu S, Lyu H, Ming GL, Wade H, Song H, Qian J, Zhu H. DNA methylation presents distinct binding sites for human transcription factors. Elife. 2013 Sep 03; 2:e00726. View on PubMed
  19. Shin J, Ming GL, Song H. By hook or by crook: multifaceted DNA-binding properties of MeCP2. Cell. 2013 Feb 28; 152(5):940-2. View on PubMed
  20. Bhang SH, Park J, Yang HS, Shin J, Kim BS. Platelet-rich plasma enhances the dermal regeneration efficacy of human adipose-derived stromal cells administered to skin wounds. Cell Transplant. 2013; 22(3):437-45. View on PubMed

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