Funded Research

• Charles Craik, PhD and Michael Evans, PhD
  Beyond ligand/receptor complexes: maximizing tumor responses to targeted radiotherapy with a conditionally activated membrane binding probe.
• Adam Renslo, PhD and Michael Evans, PhD
  Evaluating the in vivo efficacy and molecular pharmacology of artefenomel in castration-resistant prostate cancer models.
• Michael McManus, PhD
  Unlocking the key drivers and dependencies of Prostate Cancer using CRISPR GEMMS

About the BIPCR Molecular Oncology Program Awards

The Benioff Initiative for Prostate Cancer Research has provided project funding to support proposals from the HDFCCC Molecular Oncology Program. The funding is intended to address the serious unmet need for new therapeutic treatments for prostate cancer patients, particularly those with aggressive metastatic disease.

RAP Fall 2021 Cycle Awardees

• Paola Betancur, PhD
  Generating a Pipeline for Mining a Pan-cancer Gene Signature for the Prediction of Patients’ Survival and Response to Therapies
• Amit Sabnis, MD
  Probing a Synthetic Lethal Relationship between the PAX3-FOXO1 Oncogene and UCHL5
• Alison Rustagi, MD, PhD
  Improving Lung Cancer Screening Implementation: Piloting Methods to Ascertain Screening Tests and Harms in Outcomes in the Veterans Health Administration
• Manish Aghi, MD, PhD
  Replicating Retroviral Delivery of Immunomodulatory Genes to Glioblastoma
• Sanziana Roman MD, FACS
  Near-infrared Autofluorescence Imaging to Differentiate Benign and Malignant Adrenocortical Tumors
• Daniel Johnson, PhD
  Development of a Pharmacokinetic Assay for a Decoy Oligonucleotide Drug Targeting the STAT3 Transcription Factor
• Mary Helen Barcellos-Hoff, PhD
  Virotherapy Targeting TGFβ to Overcome Therapeutic Resistance in Glioblastoma

For more information on the cancer research projects above, read our news story.

About the RAP Awards

The Resource Allocation Program (RAP) is a campus-wide program whose aim is to coordinate intramural research funding opportunities for the UCSF community. Through RAP, the Cancer Center and other UCSF agencies provide seed funding to encourage clinical investigators, especially those at the beginning of their career, to initiate promising projects that may enable them to compete successfully for national research grants. Targeted areas are innovative pilot and phase I/II studies and other projects in clinical, health policy, health services, and psychosocial and behavioral research.

• Emily Finlayson, MD, MS, FACS
  PrehabPal: A digital tool to help frail elders prepare for cancer surgery

About the Emerson Collective Digital Oncology Care Awards:

The Emerson Collective invited grant applications for solutions that implement evidence-based research findings to improve patient health outcomes for clinical practice in oncology. They aimed to offer funding that initiates new prototypes or new pilot studies of digital health solutions that engage patients with a team of care providers.

• Wendell Lim, PhD
  Geographic targeting of brain metastases using synNotch-CAR T cells
• Alexander Marson, MD, PhD
  Engineering gene programs for enhanced allogeneic T cell therapies
• Arun Wiita, MD, PhD
  Search & DESTOI: a strategy to degrade intracellular oncoproteins

About the Emerson Collective Cancer Research Fund Awards:

The Emerson Collective Cancer Research Fund requested individual or team proposals with potential to significantly impact our understanding of and/or approaches to the prevention, diagnosis, or treatment of cancer. Topics were to include: engineering allogeneic cells with new properties; validating new target antigens for cell therapy in cancer; targeted intracellular gene or protein delivery mechanisms; or enabling early cancer detection.

Computational Cancer Research 2021 Awardees

• Trever Bivona, MD, PhD
  Deep learning-based characterization of the drug tolerant persister cell state in lung cancer
• Jocelyn Chapman, MD
  Predicting homologous recombination deficient ovarian cancer from clinical sequencing
• Aaron Diaz, PhD
  Target discovery for chimeric-antigen receptor T cells in pediatric brain tumors based on an analysis of alternative splicing
• Julian Hong, MD, MS
  Artificial intelligence approaches to reduce disparities in supportive care during cancer therapy

About the Computational Cancer Research Awards:

Through a generous donation, the Helen Diller Family Comprehensive Cancer Center sought applications for projects in computational cancer research, highlighting a new Cancer Center initiative focusing on Data Science. Projects were to focus on: (1) addressing an important problem in cancer through the analysis of existing data sets; and (2) developing or utilizing novel data science methods to reveal new insights in cancer biology, etiology, treatment, or other clinically relevant areas.
 

Pancreatic Cancer 2021 Awardees

• Andrew Ko, MD
  Delving into HR-Deficient Pancreatic Cancer: Navigating a Panel vs. Whole Genome Approach
• Sarah Knox, PhD
  Define the role of nerve-tumor interactions in promoting pancreatic ductal adenocarcinoma progression
• Jeroen Roose, PhD
  A PDAC organoid biobank with single-cell characterization

About the Pancreatic Cancer RFA

Pancreatic Ductal Adenocarcinoma (PDA) is a deadly disease that is the focus of numerous basic and translational scientists at UCSF. However, progress against the disease has come slowly, if at all. This has discouraged some investigators from focusing on PDA because the metrics for success may seem too difficult to achieve. Thanks to a generous donation from the Shorenstein Foundation, the Helen Diller Family Comprehensive Cancer Center was able to fund investigators with ongoing basic and/or translational research projects that could logically be expanded to include pancreatic adenocarcinoma.

The Cancer League 2021 Awardees

• Alex Marson, MD, PhD
  Use of CRISPR technology to improve T cell-based immunotherapy cancer treatments.
• Kelly Schoenbeck, MD
  Evaluating TKI-associated cognitive dysfunction in patients with chronic myeloid leukemia (CML) in chronic phase

About The Cancer League

The Cancer League's primary interest is in funding research projects that need seed money to gain traction or to get closer to a clinical trial. In addition, projects that take an existing form of treatment, but make it better or more palatable for the patient population are equally as welcomed.

Junior Cancer Researcher 2021 Awardees

• Matthew Spitzer, PhD
  "Defining the Cellular and Molecular Characteristics of Immunotherapy-Responsive Tumors using Multiplexed Ion Beam Imaging of Archival Tumor Biopsies"

About the HDFCCC Junior Cancer Researcher Award

Thanks to a generous donation, the Helen Diller Family Comprehensive Cancer Center sought applications from junior researchers with an interest in working on high-risk high-reward projects in cancer. Funding was intended for individuals who wanted to apply novel approaches to solve major cancer-specific challenges, especially those with potential clinical impact. 

Artificial Intelligence, Imaging & Cancer 2021 Awardees

• Peder Larson, PhD
  Scaling the Impact of PSMA-PET in Prostate Cancer with AI-based Imaging Biomarkers
• Janine Lupo, PhD
  Integrating Metabolic and Physiologic MRI with Deep Learning to Predict Regions of Progression in Patients with Glioblastoma

About the AI, Imaging & Cancer Awards

Through a generous donation, the Helen Diller Family Comprehensive Cancer Center sought projects applying machine learning or artificial intelligence (AI) techniques to imaging data in cancer. Projects were to focus on an innovative idea using imaging data along with AI to improve diagnosis, treatment selection, response assessment, or prognosis of cancer.