University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

CCGL: Clinical Cancer Genomics Laboratory

Assembling Version 3 of the UCSF500 Cancer Gene Panel

The CCGL has recently validated and launched the UCSF500 cancer panel for patient care. The panel is used on clinical samples, sequencing both tumor and normal tissue to identify the drivers within a patient’s tumor and potential therapeutic targets. To request UCSF500 testing, please visit this webpage.

We are now designing version 3 of the UCSF500 and are accepting gene requests. As in previous versions, the assay uses hybridization-based target enrichment of approximately 500 cancer genes for sequencing and analysis of mutation and copy number changes. Selected genes are also analyzed for structural rearrangements (listed separately below). The assay does not assess epigenetic alterations.

Genes that will be included

All coding regions of these genes will be tiled on version 3 of the UCSF500 panel.  This will allow for mutation detection (including single nucleotide variants and small insertions/deletions) as well as copy number detection (amplification and deletion) in these genes.

Rearrangements that will be included

Select introns of these genes will be tiled on version 3 of the UCSF500 panel for fusion and other rearrangement detection.

Genes that will be removed 

This list contains legacy genes not frequently mutated in cancer. None of the genes below are included in tests by Foundation Medicine, Invitae, or MSK-IMPACT. 

Submit Gene Request

Submission for Version 3 of the UCSF 500 Panel is open until September 17, 2018.

Submit your requests here.