Research Summary

Our cancer research program concentrates on understanding and interfering with cancer cell fitness. We investigate cancer-host cell interactions and capitalize on our biobanked cancer organoids and combination of epithelial cell biology and immunology.  

Jeroen Roose is a tenured Principal Investigator and Vice Chair of Anatomy at the University of California, San Francisco. He is also a co-founder of UCSF's Bakar ImmunoX Immunology Program, co-lead of UCSF’s AutoIPI(AutoImmunoProfiler), and co-lead on the UCSF Endeavor program. During his PhD, he trained with Professor Hans Clevers and investigated Wnt signaling in cancer. His postdoctoral training with Professor Arthur Weiss focused on Ras signaling in T lymphocytes. Dr. Roose also runs an organoid disease to biology unit connected to UCSF's CoLabs. Dr. Roose has advisory functions for the Mark Foundation for Cancer Research.

The Roose lab as a whole focuses on understanding cell fate decisions and cell fitness driven by cell-cell interactions and signaling pathways, in the context of cancer, autoimmune diseases, and COVID-19. By taking a collaborative approach working with biophysicists, computational engineers, geneticists, and many clinicians, the Roose research team spans the gamut from fundamental to pre-clinical science. There is a rich training environment for staff, students, postdocs, and fellows in the established infrastructure of the Roose lab and the programs it is connected to. Jeroen Roose is a recipient of multiple grants and awards including support from the NIH, foundations, philanthropy, and industry.

For more information on research directions, projects, and publications, please visit our website at rooselab.ucsf.edu or at Roose Lab UCSF (@roose_jeroen) / Twitter

Research Funding

  • April 1, 2023 - March 31, 2028 - Roles for Intracellular pH dynamics in cancer , PI . Sponsor: NIH/NCI, Sponsor Award ID: 2 R01 CA197855
  • May 1, 2022 - April 30, 2027 - Defining the unique properties of the distinct signaling machinery used by the TCR , Co-Lead/PI . Sponsor: NIH/NIAID, Sponsor Award ID: 3P01 AI091580
  • January 1, 2022 - December 30, 2026 - Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence , PI . Sponsor: NIH/NCI, Sponsor Award ID: 2R01 CA187318
  • August 1, 2022 - July 30, 2026 - Defining and re-engineering the DTC and metastatic cell surface to prevent lethal breast cancer metastasis , PI . Sponsor: DoD, Sponsor Award ID: W81XWH-22-2-0007 (BC210386P4)
  • December 1, 2020 - November 30, 2023 - Understand and Eliminate Metastatic Cancer , Co-Lead/PI . Sponsor: Mark Foundation for Cancer Research, Sponsor Award ID: A136299
  • March 1, 2014 - May 31, 2022 - Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56AI104789
  • July 15, 2011 - June 30, 2021 - Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI091580
  • August 15, 2015 - April 30, 2021 - Balanced signaling cues to guide cell transitions in the blood lineage continuum , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL120724
  • July 1, 2015 - June 30, 2020 - Molecular understanding of cytokine-Ras signals in leukemic bone marrow , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA187318
  • March 1, 2014 - February 28, 2019 - Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI104789

Education

University of Utrecht, The Netherlands, MS, 1993, Medical Biology
University of Utrecht, The Netherlands, PhD, 1999, Immunology/Transcription
University of Utrecht, The Netherlands, Fellowship, 1997-1999, Immunology/Transcription
University of California San Francisco, San Francisco, Fellowship, 1999-2004, Immunology/Signaling

Honors & Awards

  • 2012
    Gabrielle's Angel Foundation Award
  • 2013
    9th annual Mentoring award by the UCSF PSA (Postdoctoral Scholar’s Association)
  • 2014
     R01 Award (NIH; NIAID)
  • 2015
    R01 Award (NIH; NCI)
  • 2015
    Alex's Lemonade Stand Foundation Innovator Award
  • 2015
    R01 Award (NIH; NHLBI)
  • 2016
    Renewal P01 Award (NIH; NIAID)
  • 2020 -
    Endeavor Award (Mark Foundation for Cancer Research)
  • 2021
    Renewal R01 Award (NIH; NCI)
  • 2022
    Renewal P01 Award (NIH; NIAID)

Selected Publications

  1. Hendley AM, Ashe S, Urano A, Ng M, Phu TA, Peng XL, Luan C, Finger AM, Jang GH, Kerper NR, Berrios DI, Jin D, Lee J, Riahi IR, Gbenedio OM, Chung C, Roose JP, Yeh JJ, Gallinger S, Biankin AV, O'Kane GM, Ntranos V, Chang DK, Dawson DW, Kim GE, Weaver VM, Raffai RL, Hebrok M. nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer. bioRxiv. 2024 Sep 25.  View on PubMed
  2. Audrey M Hendley, Sudipta Ashe, Atsushi Urano, Martin Ng, Tuan A Phu, Xianlu Laura Peng, Changfei Luan, Anna-Marie Finger, Gun Ho Jang, Natanya R Kerper, David I Berrios, David Jin, Jonghyun Lee, Irene R Riahi, Oghenekevwe M Gbenedio, Christina Chung, Jeroen P Roose, Jen Jen Yeh, Steven Gallinger, Andrew V Biankin, Grainne M O’Kane, Vasilis Ntranos, David K Chang, David W Dawson, Grace E Kim, Valerie M Weaver, Robert L Raffai, Matthias Hebrok. Abstract A066: nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer. Cancer Research. 2024 Sep 15; 84(17_Supplement_2):a066-a066.  View on PubMed
  3. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Sci Adv. 2024 Aug 02; 10(31):eadm8836.  View on PubMed
  4. Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. Sci Rep. 2024 07 04; 14(1):15351.  View on PubMed
  5. Haderk F, Chou YT, Cech L, Fernández-Méndez C, Yu J, Olivas V, Meraz IM, Barbosa Rabago D, Kerr DL, Gomez C, Allegakoen DV, Guan J, Shah KN, Herrington KA, Gbenedio OM, Nanjo S, Majidi M, Tamaki W, Pourmoghadam YK, Rotow JK, McCoach CE, Riess JW, Gutkind JS, Tang TT, Post L, Huang B, Santisteban P, Goodarzi H, Bandyopadhyay S, Kuo CJ, Roose JP, Wu W, Blakely CM, Roth JA, Bivona TG. Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nat Commun. 2024 May 03; 15(1):3741.  View on PubMed
  6. Lisa Miller-Phillips, Imene Boukhalfa Hanafi, Alexis J. Combes, Shabana Bano, Lisiena Hysenaj, Jeroen P. Roose, Adam Olshen, Ashley Kiemen, Sarah Umetsu, Man-Tzu Wang, Eric A. Collisson. Abstract 7465: Leukemia inhibitory factor creates an immune suppressive tumor microenvironment and fosters tumor growth in KRAS-driven pancreatic ductal adenocarcinoma. Cancer Research. 2024 Mar 22; 84(6_Supplement):7465-7465.  View on PubMed
  7. Audrey M. Hendley, Atsushi Urano, Xianlu L. Peng, Sudipta Ashe, Tuan A. Phu, Martin Ng, Natanya R. Kerper, David I. Berrios, Jonghyun Lee, David Jin, Gun H. Jang, Oghenekevwe M. Gbenedio, Jeroen P. Roose, Jen J. Yeh, Steven Gallinger, Andrew V. Biankin, Vasilis Ntranos, David K. Chang, David W. Dawson, Grace E. Kim, Valerie M. Weaver, Robert L. Raffai, Matthias Hebrok. Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma. Cancer Research. 2024 Jan 16; 84(2_Supplement):a046-a046.  View on PubMed
  8. Karra L, Finger AM, Shechtman L, Krush M, Huang RM, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Gonzalez PG, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP. Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions. bioRxiv. 2023 Dec 20.  View on PubMed
  9. Chang Y, Manivannan P, Doosti A, Lapinski PE, Chen D, Roose JP, King PD. Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling. J Immunol. 2023 09 15; 211(6):917-922.  View on PubMed
  10. Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression. Cancer Cell. 2023 05 08; 41(5):853-870.e13.  View on PubMed
  11. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem Cell Reports. 2023 03 14; 18(3):636-653.  View on PubMed
  12. Hugo Gonzalez, Wenbin Mei, Isabella Robles, Catharina Hagerling, Breanna Allen, Trine Hauge Okholm, Ankitha Nanjaraj, Tamara Verbeek, Sandhya Kalavacherla, Merel van Gogh, Stephen Georgiou, Mariza Daras, Joanna J. Phillips, Matthew H. Spitzer, Jeroen P. Roose, Zena Werb. Abstract IA022: Cell archetypes in human brain metastases: Connecting programs in tumor cells with the microenvironment. Cancer Research. 2023 Jan 15; 83(2_Supplement_2):ia022-ia022.  View on PubMed
  13. Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. bioRxiv. 2022 Aug 02.  View on PubMed
  14. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17.  View on PubMed
  15. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11.  View on PubMed
  16. Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice. Leukemia. 2022 04; 36(4):1167-1170.  View on PubMed
  17. Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z. Cellular architecture of human brain metastases. Cell. 2022 02 17; 185(4):729-745.e20.  View on PubMed
  18. Roose J, Barton G. Editorial overview: Communities in immune cell signaling. Curr Opin Immunol. 2021 12; 73:iii-iv.  View on PubMed
  19. Kriti Bahl, Darienne Myers, Jeroen Roose. 603 Autoreactivity drives increased metabolism in T cells from SLE patients?. Lupus Science & Medicine. 2021 Nov 1; 8(Suppl 2):a22-a23.  View on PubMed
  20. Wen Z, Yun G, Hebert A, Kong G, Ranheim EA, Finn R, Rajagoplan A, Li S, Zhou Y, Yu M, Damnernsawad A, Roose JP, Coon JJ, Wen R, Wang D, Zhang J. Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors. Blood. 2021 06 10; 137(23):3259-3271.  View on PubMed

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