Jeroen Roose, PhD
Professor, Department of Anatomy, UCSF
Cancer Center Program Memberships
Hematopoietic MalignanciesResearch Summary
I obtained my PhD in The Netherlands where I investigated Wnt signaling and cancer in the lab of Dr. Hans Clevers. I subsequently studied Ras signaling in lympohcytes during my postdoc in the lab of Dr. Arthur Weiss at UCSF. Since 2007 I built my own research group as an independent investigator in the department of Anatomy at UCSF. I am currently a tenured Associate Professor with a team of staff members, graduate students, postdoctoral fellows, and Master’s students. Our focus is on Ras-kinase signaling an implications of signal alterations in human disease,Half of my group currently focuses on various aspects of Ras signaling and cancer. We have published on the leukemic role of the Ras activator Rasgrp1 in both T cell leukemia and in myeloid leukemia. We reported on two biochemically distinct oncogenic Ras signals in T cell leukemia. We continue this research area with the goal of improving molecular therapy for leukemia patients. We expanded our research to carcinomas and reported that the EGFR sends not only growth-stimulatory cues in colorectal cancer but also growth-restricting signals, depending on the use of the SOS1- or RasGRP1- Ras activators.
We are part of the Biomedical Science (BMS) Graduate Program, the Immunology Program, the Helen Diller Family Comprehensive Cancer Center, and the Stem Cell Center. For more information on research directions, projects, and publications, please visit our website at rooselab.ucsf.edu.
Education
University of Utrecht, The Netherlands, MS, 1993, Medical Biology
University of Utrecht, The Netherlands, PhD, 1999, Immunology/Transcription
University of Utrecht, The Netherlands, Fellowship, 1997-1999, Immunology/Transcription
University of California San Francisco, San Francisco, Fellowship, 1999-2004, Immunology/Signaling
Professional Experience
-
2004-2006
Adjunct Instructor, Div. of Rheumatology, Dept. of Medicine, UCSF, San Francisco -
2006-2007
Assistant Adjunct Professor, Div. of Rheumatology, Dept. of Medicine, UCSF, San Francisco -
2007-2014
Assistant Professor, Dept. of Anatomy, School of Medicine, UCSF, San Francisco -
2014-2018
Associate Professor, Dept. of Anatomy, School of Medicine, UCSF, San Francisco -
2018-present
Professor, Dept. of Anatomy, School of Medicine, UCSF, San Francisco
Honors & Awards
Past 5 years:
- 2012
Gabrielle's Angel Foundation Award - 2013
9th annual Mentoring award by the UCSF PSA (Postdoctoral Scholar’s Association) - 2014
R01 Award (NIH; NIAID) - 2015
R01 Award (NIH; NCI) - 2015
Alex's Lemonade Stand Foundation Innovator Award - 2015
R01 Award (NIH; NHLBI) - 2016
Renewal P01 Award (NIH; NIAID)
Selected Publications
Cancer-related publications over the past 5 years:
- Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT. One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nat Struct Mol Biol. 2016 Sep;23(9):838-46. doi: 10.1038smb.3275. Epub 2016 Aug 8. PMCID: PMC5016256
- Mues M, Roose JP. Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle. Small GTPases. 2016 May 9; 1-6. PMID: 27159504
- Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 6; 36(1):142-52. PMID: 26740656.
- RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to pro-tumorigenic cytokines. Olga Ksionda, Alexis A. Melton, Juliane Bache, Milou Tenhagen, Jeroen Bakker, Richard Harvey, Stuart S. Winter, Ignacio Rubio and Jeroen P. Roose. Oncogene, November 2015. PMID 26549032
- Philippe Depeille and Jeroen P. Roose. Flavors of EGFR-Ras signals Impacting Intestinal Homeostasis. Cell Cycle, August 2015. PMID: 26292152
- Philippe Depeille, Robert Warren, and Jeroen P. Roose. Unexpected Insights relevant to anti-EGFR therapy in colorectal cancer. OncoTarget, August 2015. PMID: 26300054
- Philippe Depeille, Linda M. Henricks, Robert A. H. van de Ven, Ed Lemmens, Chih-Yang Wang, Mary Matli, Zena Werb, Kevin M. Haigis, David Donner, Robert Warren, and Jeroen P. Roose. RasGRP1 Opposes Proliferative EGFR-SOS1 Ras Signals and Restricts Intestinal Epithelial Cell Growth. Nature Cell Biology, May 2015. PMID 26005835
- Beth A. Lubeck, Philip E. Lapinski, Jennifer A. Oliver, Olga Ksionda, Luis F. Parada, Yuan Zhu, Ivan Maillard, Mark Chiang, Jeroen Roose and Philip D. King. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. Journal of Immunology, May 2015. PMCID: PMC4475412
- Ernesto Diaz-Flores, Hana Goldschmidt, Philippe Depeille, Victor Ng, Kimberly Krisman, Michael Crone, Olusegun Williams, Benjamin Houseman, Kevan Shokat, Deepak Sampath, Gideon Bollag, Jeroen P. Roose, Benjamin S. Braun, and Kevin Shannon. PLCgamma and PI3 Kinase Link Cytokine Stimulation to ERK Activation in Primary Hematopoietic Cells Expressing Normal and Oncogenic Kras. Science Signaling, December 2013. PMCID: PMC4117477
- Olga Ksionda, Andre Limnander, and Jeroen Roose. Rasgrp Ras Guanine Nucleotide Exchange Factors in Cancer. Frontiers in Biology, October 2013. PMCID: PMC3987922
- Jesse E. Jun, Ignacio Rubio, and Jeroen Roose. Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T cells. Frontiers in Immunology, September 2013. PMCID: PMC3762125
- Jeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose# and John Kuriyan#. The Structural Basis for Autoinhibition of the Ras-specific exchange factor RasGRP1. eLIFE, 2013 July. PMCID: PMC3728621
- Chakraborty, A. and Roose, J.. Biochemical Heterogeneity and Developmental Varieties in T cell Leukemia. Cell Cycle, 2013 May. PMCID: PMC3680523
- Catherine Hartzell, Olga Ksionda, Ed Lemmens, Kristen Coakley, Ming Yang, Richard Harvey, Christopher Govern, Jeroen Bakker, Tineke Lenstra, Monique Dail, Kristin Ammon, Anne Boeter, Mignon Loh, Stuart Winter, Kevin Shannon, Arup K. Chakraborty, Matthias Wabl, and Jeroen P. Roose. Effective Synergy between Cytokine Receptor-input and the Rasgrp1 Oncogene in T cell leukemogenesis. Science Signaling. March 26 2013. PMCID: PMC3737252