Research Summary

Our cancer research program concentrates on understanding and interfering with cancer cell fitness. We investigate cancer-host cell interactions and capitalize on our biobanked cancer organoids and combination of epithelial cell biology and immunology.  

Jeroen Roose is a tenured Principal Investigator and Vice Chair of Anatomy at the University of California, San Francisco. He is also a co-founder of UCSF's Bakar ImmunoX Immunology Program, co-lead of UCSF’s AutoIPI(AutoImmunoProfiler), and co-lead on the UCSF Endeavor program. During his PhD, he trained with Professor Hans Clevers and investigated Wnt signaling in cancer. His postdoctoral training with Professor Arthur Weiss focused on Ras signaling in T lymphocytes. Dr. Roose also runs an organoid disease to biology unit connected to UCSF's CoLabs. Dr. Roose has advisory functions for the Mark Foundation for Cancer Research.

The Roose lab as a whole focuses on understanding cell fate decisions and cell fitness driven by cell-cell interactions and signaling pathways, in the context of cancer, autoimmune diseases, and COVID-19. By taking a collaborative approach working with biophysicists, computational engineers, geneticists, and many clinicians, the Roose research team spans the gamut from fundamental to pre-clinical science. There is a rich training environment for staff, students, postdocs, and fellows in the established infrastructure of the Roose lab and the programs it is connected to. Jeroen Roose is a recipient of multiple grants and awards including support from the NIH, foundations, philanthropy, and industry.

For more information on research directions, projects, and publications, please visit our website at rooselab.ucsf.edu or at Roose Lab UCSF (@roose_jeroen) / Twitter

Research Funding

  • April 1, 2023 - March 31, 2028 - Roles for Intracellular pH dynamics in cancer , PI . Sponsor: NIH/NCI, Sponsor Award ID: 2 R01 CA197855
  • May 1, 2022 - April 30, 2027 - Defining the unique properties of the distinct signaling machinery used by the TCR , Co-Lead/PI . Sponsor: NIH/NIAID, Sponsor Award ID: 3P01 AI091580
  • January 1, 2022 - December 30, 2026 - Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence , PI . Sponsor: NIH/NCI, Sponsor Award ID: 2R01 CA187318
  • August 1, 2022 - July 30, 2026 - Defining and re-engineering the DTC and metastatic cell surface to prevent lethal breast cancer metastasis , PI . Sponsor: DoD, Sponsor Award ID: W81XWH-22-2-0007 (BC210386P4)

Education

University of Utrecht, The Netherlands, MS, 1993, Medical Biology
University of Utrecht, The Netherlands, PhD, 1999, Immunology/Transcription
University of Utrecht, The Netherlands, Fellowship, 1997-1999, Immunology/Transcription
University of California San Francisco, San Francisco, Fellowship, 1999-2004, Immunology/Signaling

Honors & Awards

  • 2012
    Gabrielle's Angel Foundation Award
  • 2013
    9th annual Mentoring award by the UCSF PSA (Postdoctoral Scholar’s Association)
  • 2014
     R01 Award (NIH; NIAID)
  • 2015
    R01 Award (NIH; NCI)
  • 2015
    Alex's Lemonade Stand Foundation Innovator Award
  • 2015
    R01 Award (NIH; NHLBI)
  • 2016
    Renewal P01 Award (NIH; NIAID)
  • 2020 -
    Endeavor Award (Mark Foundation for Cancer Research)
  • 2021
    Renewal R01 Award (NIH; NCI)
  • 2022
    Renewal P01 Award (NIH; NIAID)

Selected Publications

  1. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem Cell Reports. 2023 Feb 08.  View on PubMed
  2. Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. NF-?B inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. bioRxiv. 2022 Aug 02.  View on PubMed
  3. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17.  View on PubMed
  4. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11.  View on PubMed
  5. Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice. Leukemia. 2022 04; 36(4):1167-1170.  View on PubMed
  6. Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z. Cellular architecture of human brain metastases. Cell. 2022 02 17; 185(4):729-745.e20.  View on PubMed
  7. Roose J, Barton G. Editorial overview: Communities in immune cell signaling. Curr Opin Immunol. 2021 12; 73:iii-iv.  View on PubMed
  8. Kriti Bahl, Darienne Myers, Jeroen Roose. 603 Autoreactivity drives increased metabolism in T cells from SLE patients?. Lupus Science & Medicine. 2021 Nov 1; 8(Suppl 2):a22-a23.  View on PubMed
  9. Wen Z, Yun G, Hebert A, Kong G, Ranheim EA, Finn R, Rajagoplan A, Li S, Zhou Y, Yu M, Damnernsawad A, Roose JP, Coon JJ, Wen R, Wang D, Zhang J. Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors. Blood. 2021 06 10; 137(23):3259-3271.  View on PubMed
  10. Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP. SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator. bioRxiv. 2021 Jun 02.  View on PubMed
  11. Bahl K, Roose JP. T cells: a dedicated effector kinase pathways for every trait? Biochem J. 2021 03 26; 478(6):1303-1307.  View on PubMed
  12. Karra L, Roose JP. Investigating increased hematopoietic stem cell fitness in a novel mouse model. Small GTPases. 2022 01; 13(1):7-13.  View on PubMed
  13. Li PJ, Roose JP, Jablons DM, Kratz JR. Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models. Cancers (Basel). 2021 Feb 09; 13(4).  View on PubMed
  14. Kulhanek KR, Roose JP, Rubio I. Regulation of the Small GTPase Ras and Its Relevance to Human Disease. Methods Mol Biol. 2021; 2262:19-43.  View on PubMed
  15. Baars MJD, Douma T, Simeonov DR, Myers DR, Kulhanek K, Banerjee S, Zwakenberg S, Baltissen MP, Amini M, de Roock S, van Wijk F, Vermeulen M, Marson A, Roose JP, Vercoulen Y. Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity. Eur J Immunol. 2021 02; 51(2):471-482.  View on PubMed
  16. Karra L, Romero-Moya D, Ksionda O, Krush M, Gu Z, Mues M, Depeille P, Mullighan C, Roose JP. Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis. Oncogene. 2020 11; 39(45):6920-6934.  View on PubMed
  17. Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, R?sch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In�Vivo. Cell Stem Cell. 2020 11 05; 27(5):840-851.e6.  View on PubMed
  18. Kulhanek KR, Myers DR, Ksionda O, Vercoulen Y, Romero-Moya D, Roose JP. Protocol for Barcoding T Cells Combined with Timed Stimulations. STAR Protoc. 2020 09 18; 1(2):100067.  View on PubMed
  19. Romero-Moya D, Roose JP. Protocol for Comprehensive Synthetic Lethality Screens. STAR Protoc. 2020 06 19; 1(1).  View on PubMed
  20. Samocha A, Doh H, Kessenbrock K, Roose JP. Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. Cancers (Basel). 2019 Sep 24; 11(10).  View on PubMed

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